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Funding Acknowledgements Type of funding sources: Public Institution(s). Main funding source(s): South Ural State Medical University Introduction. The interaction of metabolic and cardiovascular factors, united by common mechanisms of mutual interference, determines the modern concept of cardiometabolic risk. It is important to study the determinants of cardiometabolic risk factors in different phenotypes of overweight and obesity among young adults. Purpose. To study cardiometabolic risk factors in various phenotypes of overweight and obesity among young adults. Methods. Study design: cross-sectional study. The study included 251 patients. All patients were divided into 4 groups: gr. 1 - metabolically healthy individuals with normal body weight (n = 62), aged 24.5 [22-31] years; gr. 2 - metabolically unhealthy individuals with normal body weight (n = 57), aged 28 [23-38] years; gr. 3 - metabolically healthy overweight/obesity (n = 16), aged 30 [24-36] years; gr. 4 - metabolically unhealthy overweight/obesity (n = 116), aged 36 [28.5-41] years. Statistical methods: MedCalc statistical software package (2020). p &amp;lt; 0.05 were taken as statistically significant. Results. The most significant changes of carbohydrate and lipid metabolism and some hemostasis parameters with adipokine imbalance were found in metabolically unhealthy overweight/obesity (gr. 4): the highest concentrations of leptin (ng/ml): 37.9 [13.0-63.4] vs 10.0 [5.1-15.5] – gr.1; 9.5 [5.5-21.5] – gr. 2; 25.7 [4.7-37.2] – gr. 3, p4-1.2.3 &amp;lt; 0.05; fibrinogen (g/l): 4.0 [3.5-4.6] vs 3.4 [2.9-4.0] – gr. 1, 3.4 [3.1-4.0] – gr. 2, 3.4 [2.6-3.8] – gr. 3, p4-1.2.3 &amp;lt; 0.001; plasminogen activator inhibitor-1 (ng/ml): 464.5 [285.1-628.5] vs 308.2 [211.7-415.7] – gr. 1; 342.3 [222.2-490.0] – gr. 2; 371.0 [273.1-621.0] – gr. 3, p4-1 &amp;lt; 0.001, as well as the lowest concentrations of adiponectin (μg/ml): 7.9 [4.9-10.2] – gr. 3 and 7.9 [5.2-12.4] – gr. 4 compare to gr. 1 – 9.1 [7.5-12.2]) and gr. 2 – 8.7 [7.2-10.5], p3.4-1.2 &amp;lt; 0.05. In young individuals the most significant correlations were found between waist circumference, systolic and diastolic blood pressure - on the one hand, and serum concentrations of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, leptin, fibrinogen, and type 1 plasminogen activator inhibitor, on the other hand. Conclusion. Disorders of lipid and carbohydrate metabolism with adipokine imbalance in young adults determine a higher cardiometabolic risk both in overweight/obese patient and individuals with normal body mass index.

Factors of cardiometabolic risk in various phenotypes of overweight and obesity among young adults