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have also shown that Malay–Singaporean subjects, who are Asians of Austronesian descent, and Indian– Singaporean subjects, who are of South Asian descent, have an increased prevalence of the *2 LOF polymorphism when compared with Caucasian subjects. The homozygous *2 genotype, which is associated with the highest level of on-treatment platelet reactivity and is present in 2–3% of the Caucasians, was present in 6% of the Chinese, 9% of the Malays, and 13% of the Indians in our study. The prevalence of *2 polymorphisms among the Indian subjects in our study was higher than that observed in Caucasian populations but similar to other studies on Indian subjects from the Indian subcontinent. 5

Clopidogrel pharmacogenetics of east, south and other Asian populations