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at all scheduled visits, and antihypertensive treatment will be adjusted whenever ABP exceeds normal values (Figure). Results: MASTER will evaluate whether an ABPM based strategy is superior to an OBPM based strategy in changing LVmass and microalbuminuria (intermediate coprimary outcome) and in preventing CV events (secondary outcome). Conclusions: Although the superiority of ABPM over OBPM has been repeatedly shown by observational studies, key evidence from randomized intervention trials on the actual clinical value of ABPM is still missing. The results of the MASTER study will help to clarify whether an ABPM guided treatment strategy provides a greater benefit in terms of prevention/regression of organ damage and reduction in CV events than a strategy based on conventional OBP measurements. Acknowledgement/Funding: Istituto Auxologico Italiano-Univ.Milan-Bicocca. Unrestricted support by Pfizer, Daiichi-Sankyo, Omron Healthcare EU, Menarini Int., A&D Medical

P4555Incidence and predictors of severe overanticoagulation in patients with atrial fibrillation - the EWA study