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We studied 412 young adults (23.4 ± 0.5 years; 272 female) from the Avon Longitudinal Study of Parents and Children (ALSPAC) and those with BMI ≥ 30kg/m were classed as obese. Resting brachial arterial diameters and flows were measured and shear rates were calculated as 4 x timeaveraged mean velocity / diameter. Blood pressure, endothelial function (flow-mediated dilation: FMD) and arterial stiffness (carotid-radial pulse wave velocity: PWV) were also measured. In a subset of patients (n=164), 50MHz very high-resolution ultrasound (VHRUS) was used to measure radial artery diameter, intima-media thickness (IMT), and individual intima and media thicknesses (IT and MT, respectively).

1951Obese young adults exhibit early peripheral arterial remodelling but preserved conduit artery function