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was treated unevenfully with a drug-eluting balloon angioplasty. Three severely stenosed external carotid arteries (ECAs) occluded at CAS; ECA patency rate was 97.0% post CAS and at 30 days, and 97% at 12 months. At 12 months, in-stent velocities were normal (PSV 0.81±0.3; EDV 0.21±0.3m/s). Conclusions: The PARADIGM study 12-month clinical and DUS data are consistent with normal healing and sustained safety and cerebral embolism prevention efficacy of the CGuardTM stent used routinely for stroke prevention in symptomatic and increased-stroke-risk asymptomatic subjects with carotid stenosis. This indicates a paradigm shift in carotid revascularization for stroke prevention. Acknowledgement/Funding: Jagiellonian University Medical College and ’For the Heart’ Foundation

P438Beat-to-beat validation of PPG as a tool to detect regular and irregular heartbeats