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reducing inappropriate implants among patients with severely reduced EF, and in identifying patients at higher arrhythmic risk among those with moderately reduced EF. In this study we investigated the relation between new promising parameters for arrhythmic risk evaluation, derived from I123-mIBG Scintigraphy (mIBG-S), and expressed in terms of early and late Heart/Mediastinum (eH/M and lH/M) and Wash-out Rate (WR), and a composite endpoint of arrhythmic events (AE) and SCD. Data derived from a prospective observational analyses on 29 patients eligible for primary-prevention ICD implantation, according to current ESC guidelines criteria, that underwent mIBG-S before the procedure. After a median follow-up of 24 months post-implantation, 20 patients presented AE, while only 2 patients had SCD. Statistically significant correlation was observed between mIBG-S markers and arrhythmic events to follow-up (eH/M: p=0,003, lH/M: p=0,001, WR: p=0,037), while only lH/M e WR (p=0,01 and p=0,038 respectively) showed significant correlation with SCD. Moreover, in the subgroup of patients (10) with EF between 30–35%, late H/M value <1,6 maintained statistically significant correlation with the composite endpoint, compared with EF (p=0,003 vs p=0,206). Even in a small sample, these results support the hypothesis of a prognostic and additive value of the evaluation of myocardial sympathetic innervation by mIBG-S for better arrhythmic risk stratification.

european heart journal

P5528The positive result of late potential after percutaneous coronary intervention for acute coronary syndromes may help the evaluation of the cardiovascular events