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APD811 is an oral, non-prostanoid IP receptor agonist with a long plasma half-life (∼ 24 hr) in development for pulmonary arterial hypertension (PAH). Little is known about the pulmonary pharmacology of this agent. The aim was to compare the functional effects of APD811 in distal human pulmonary smooth muscle cells (PASMCs) and arteries (PAs) alongside other prostacyclin mimetics already licensed for PAH.

5021APD811 (ralinepag), a novel non-prostanoid IP receptor agonist, has potent antiproliferative and vasorelaxant properties in human pulmonary artery