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A 50-year-old man underwent primary percutaneous coronary intervention for anterior ST-segment elevation myocardial infarction 3 h after symptom onset. After thrombectomy, polarization-sensitive optical frequency domain imaging (PS-OFDI) was performed at the culprit left anterior descending artery lesion using a prototype imaging system (Wellman Center for Photomedicine). In addition to the conventional image of plaque structure, PS-OFDI provides a measure of tissue birefringence. This optical tissue property is elevated in tissue with regularly organized architecture, …

First-in-man assessment of plaque rupture by polarization-sensitive optical frequency domain imagingin vivo