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A 42-year-old-woman with known chronic pulmonary-sarcoidosis on long-term prednisone and home-oxygen therapy was referred to cardiology with symptoms of exertional chest tightness. Physical examination was notable for a palpable right-ventricular (RV) heave and a loud second heart sound (P2). Plasma B-natriuretic peptide (BNP) levels were elevated at 183 pg/mL. Transthoracic-echocardiography was suggestive of severe RV enlargement and systolic dysfunction with an estimated pulmonary systolic pressure of 60 mmHg. Cardiac magnetic resonance imaging confirmed severe RV enlargement (RVEDV = 218 mL) …

Reversal of right-ventricular dysfunction in pulmonary arterial hypertension following sildenafil therapy: