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P5683 – Table 1 Findings Control CM CV CVCM N NCM P Degeneration in tubule epithelium 0,16±0,16b 1,50±0,34a 0,14±0,14b 0,28±0,18b 0,14±0,14b 0,28±0,18 <0.01 Dilatation of tubules 0,33±0,20b 1,16±0,16a 0,28±0,18a,b 0,14±0,14a,b 0,042±0,20 0,042±0,20 <0.05 Interstitial infiltration 0,53±0,21b 1,66±0,33a 0,00±0,00b 0,57±0,20b 0,57±0,20b 0,57±0,20b <0.01 a bDifferent letters indicate statistically significant differences in the same row. Conclusions: The data suggest that the energy-production mitochondrial activity of the failing heart in CRS may be reduced compared to CKD or LVD alone. Swollen mitochondria and down-regulation of the ubiquinone pathway indicate metabolic stress, which may trigger myocyte cell death and intensify the loss of cardiac tissue. Mitochondrial destruction may thus represent a critical factor for disease progression. P5682 | BENCH Pathological examination of the woven coronary anomaly A. Abaci, I.I. Gonul, S. Ozkan, M. Cemri, A. Yener. Gazi University School of Medicine, Ankara, Turkey Woven coronary artery is an extremely rare anomaly in which the coronary artery branches into twisted multiple thin channels at one or more segments of the coronary tree, and then, these channels merge again in order to form a normal vessel. Until now, woven coronary is an angiographic diagnosis. A 46-year old man was admitted to our coronary care unit with the diagnosis of non ST-elevation ACS. Angiography revealed a 90% stenosis at the mid-segment of the LAD, and a 99% stenosis at the first diagonal artery. Along a nearly 4cm length of LAD starting from proximal segment, lumen of the vessel was divided into twisted multiple thin channels and then these twisted channels merge again just before the stenosis. The same view was present in the firs diagonal, first obtuse marginal, and right coronary artery. The diagnosis of woven coronary anomaly was made. The patient was scheduled for CABG surgery. After the grafting completed, approximately 1-cm long part of the woven segment of the LAD was excised. He had an uneventful post-operative course. Gross examination has revealed a macroscopically identifiable 3 separate lumina. When examined by light microscopy, it has been identified that actually 4 distinct lumen formation is present (figure). Each of these 4 lumina is lined by an endothelial lining as an innermost coat. However, there is a prominent thickening in the subendothelium of each, which has been mostly composed of irregular fibrosis. There is only one layer of uninterrupted internal elastic lumina surrounding all of these 4 malformed looking vascular lumina, outermost coat of which composed of a layer of tunica media with external elastic lamina and tunica adventitia.

european heart journal

Downregulated expression of genes involved in the ubiquinone biosynthesis pathway in cardiorenal syndrome is associated with histopathological changes of the mitochondria