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Conclusion: In patients after cardiac arrest in therapeutic hypothermia the nonresponder rate is extremely high. Comparing prasugrel and ticagrelor with clopidogrel, both "new" antiplatelet drugs can ameliorate platelet inhibition significantly, but still show high rates of non-responders. It is suggestive that improved platelet inhibition results in better clinical outcome. Large clinical studies have to test this hypothesis also in hypothermia.

european heart journal

Randomized comparison of the platelet inhibitory efficacy between low dose prasugrel and standard dose clopidogrel in patients receiving dual antiplatelet therapy after coronary stent implantation