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Purpose: Cardiopulmonary exercise testing (CPET) and cardiac magnetic resonance (CMR) are used to time pulmonary homograft replacement in operated TOF patients with significant pulmonary regurgitation (PR). We correlated CPET and CMR parameters in these patients. Methods: Single-centre retrospective analysis of 36 operated TOF patients (postrepair 21±7 yr; 30 NYHA I, 6 NYHA II; age 28±11 yr; 29 males) with at least moderate PR on CMR who underwent CPET within 15 (median 5, IQR 1-7) months of CMR. CPET parameters were compared with 30 ageand sex-matched healthy controls (age 30±10 years, male=24). Results: Peak oxygen consumption (VO2max) (29.0±6.5 vs 35.2±7.3 ml/kg/min, p=0.001) and peak oxygen pulse (POP) (11.6±3.8 vs 13.9±2.9 ml/beat, p=0.008) are significantly lower in TOF group vs control. No significant difference in anaerobic threshold (AT) and VE/VCO2 slope seen. Univariate analyses show negative correlation between PR fraction and AT; positive correlation between indexed left (LV) and right (RV) ventricular end-diastolic volumes and VO2max (see table). These remain significant after age and sex adjustments. RV restriction has no correlation with CPET results.

Exercise capacity correlates with ventricle size in adult operated tetralogy of Fallot