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In animals, thiazolidinediones reduce ischaemia-reperfusion injury. A clinical meta-analysis raised suspicion that rosiglitazone increases the incidence of myocardial infarction (Nissen et al. , N Engl J Med 2007;356:2457–2471). However, human data on a possible benefit on infarct size (i.e. ischaemia-reperfusion injury) are not available. Therefore, we investigated the effect of rosiglitazone on ischaemia-reperfusion injury …

Rosiglitazone reduces ischaemia-reperfusion injury in patients with the metabolic syndrome