English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

A large body of evidence indicates that resting heart rate is a strong independent predictor of cardiovascular morbidity and mortality.1–9 This association has been found to be present at all ages and in different clinical settings, irrespective of the presence of co-morbidities.1–9 The relationship was still present when subjects who died within the first years after baseline evaluation were excluded, thereby ruling out the possibility that the association between heart rate and mortality was due to some underlying chronic disease unrecognized at the time of baseline assessment.1,4,7 Overall, the results of ∼50 longitudinal studies have been published on the relationship between heart rate and total and/or cardiovascular mortality, and the large majority have demonstrated that heart rate is a strong predictor of risk whereas no study has shown the reverse.8–11 The pathogenetic mechanisms accounting for the connection between high heart rate, atherosclerosis, and cardiovascular morbidity have been documented in many laboratory and clinical studies, reinforcing the clinical validity of the epidemiologic data.12,13 A crucial step is obviously to know whether heart rate is still associated with mortality when controlling for a variety of cardiovascular risk factors. All but one analysis demonstrated that heart rate was an independent risk factor and that the risk was graded across the heart rate range.8,9 On the basis of this evidence, heart rate has been included by several Scientific Authorities into scoring systems that can be used to predict all-cause mortality risk.14,15 In the clinical score sheet developed by the Cooper Clinic panellists, high heart rate received as many risk factor points as hypertension or low cardiorespiratory fitness assessed with exercise testing.14 The main goal of a clinical score sheet is … *Corresponding author. Tel: +39 049 8212278, Fax: +39 049 8754179, Email: palatini{at}unipd.it

Is there benefit of cardiac slowing drugs in the treatment of hypertensive patients with elevated heart rate?