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Several studies have reported superior post-cardioplegic recovery after glutamate supplementation. The optimum dose of glutamate supplementation is unknown. The purpose of this study was to find the optimal protective concentration of glutamate supplementation in a model of ischaemia/cardioplegia and reperfusion.

A dose–response study of glutamate supplementation in isolated, perfused rat hearts undergoing ischaemia and cold cardioplegia