Open AccessElevated serum microRNA 483-5p levels may predict patients at risk of post-operative atrial fibrillation
Author(s) -
Leanne Harling,
Jonathan Lambert,
Hutan Ashrafian,
Ara Darzi,
Nigel J. Gooderham,
Thanos Athanasiou
Publication year - 2016
Publication title -
european journal of cardio-thoracic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.303
H-Index - 133
eISSN - 1873-734X
pISSN - 1010-7940
DOI - 10.1093/ejcts/ezw245
Subject(s) - atrial fibrillation , medicine , cardiology , sinus rhythm , biomarker , receiver operating characteristic , artery , coronary sinus , biochemistry , chemistry
Post-operative atrial fibrillation (POAF) is the commonest post-operative cardiac arrhythmia, affecting ∼1 in 3 patients undergoing coronary artery bypass grafting (CABG). Although its aetiology is complex, atrial substrate changes may pre-dispose to its onset. This study aims to ascertain the atrial microRNA signature of POAF and determine the potential for circulating microRNA as a pre-operative biomarker for this arrhythmia.
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