Open AccessA promoter polymorphism -945C>G in the connective tissue growth factor in heart failure patients with mechanical circulatory support: a new marker for bridge to recovery?
Author(s) -
Maximilian Posch,
G. Schmidt,
Laura Allison Steinhoff,
Andreas Perrot,
Thorsten Drews,
Michael Dandel,
Thomas Krabatsch,
Roland Hetzer,
Evgenij Potapov
Publication year - 2014
Publication title -
european journal of cardio-thoracic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.303
H-Index - 133
eISSN - 1873-734X
pISSN - 1010-7940
DOI - 10.1093/ejcts/ezu402
Subject(s) - ctgf , medicine , cardiac function curve , connective tissue , dilated cardiomyopathy , heart failure , muscle hypertrophy , cardiac fibrosis , allele , gastroenterology , cardiology , growth factor , biology , pathology , genetics , receptor , gene
Mechanical circulatory support (MCS) creates improvement of cardiac function in a small portion of patients with idiopathic dilated cardiomyopathy (iDCM). Among other factors, cardiomyocyte hypertrophy seems to represent an important prerequisite for MCS-related cardiac recovery. We have previously shown that connective tissue growth factor (CTGF) leads to adaptive cardiomyocyte hypertrophy associated with a protective cardiac function in transgenic mice. To test whether a functional genetic variant in the CTGF promoter impacts MCS-related cardiac recovery, three groups of iDCM patients with and without cardiac recovery on MCS were genotyped.
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