Haemodynamic unloading increases the survival and affects the differentiation of cardiac stem cells after implantation into an infarcted heart
Author(s) -
Hiroshi Kurazumi,
TaoSheng Li,
Yasuhiko Takemoto,
Ryo Suzuki,
Akihito Mikamo,
ChaoYu Guo,
Tomoaki Murata,
Kimikazu Hamano
Publication year - 2014
Publication title -
european journal of cardio-thoracic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.303
H-Index - 133
eISSN - 1873-734X
pISSN - 1010-7940
DOI - 10.1093/ejcts/ezt629
Subject(s) - hemodynamics , stem cell , cardiology , medicine , transplantation , cardiac output , myocardial infarction , andrology , biology , microbiology and biotechnology
It has been anticipated that stem cell therapy is capable of repairing an injured heart but is currently limited by its marginal efficacy. We believe that mechanical stress due to haemodynamic loading may negate the therapeutic potency of stem cells and therefore investigated how haemodynamic unloading affects the survival and differentiation of stem cells after implantation into an infarcted heart.
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