Open AccessSuccessful prolonged ex vivo lung perfusion for graft preservation in rats
Author(s) -
Kentaro Noda,
Norihisa Shigemura,
Yugo Tanaka,
Jay K. Bhama,
Jonathan D’Cunha,
James D. Luketich,
C. Bermúdez
Publication year - 2014
Publication title -
european journal of cardio-thoracic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.303
H-Index - 133
eISSN - 1873-734X
pISSN - 1010-7940
DOI - 10.1093/ejcts/ezt598
Subject(s) - ex vivo , perfusion , lung , medicine , pathology , in vivo , biology , cardiology , microbiology and biotechnology
Ex vivo lung perfusion (EVLP) strategies represent a new frontier in lung transplantation technology, and there have been many clinical studies of EVLP in lung transplantation. The establishment of a reliable EVLP model in small animals is crucial to facilitating translational research using an EVLP strategy. The main objective of this study was to develop a reproducible rat EVLP (R-EVLP) model that enables prolonged evaluation of the explanted lung during EVLP and successful transplantation after EVLP.
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