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The receptor activator of the nuclear factor kappa-B (NF-κB) ligand (RANKL), its membrane receptor RANK and its decoy receptor osteoprotegerin (OPG) are all members of the tumour necrosis factor family involved in bone metabolism and immune response. We evaluated the activation of the OPG/RANKL/RANK pathway in patients undergoing cardiac surgery with and without cardiopulmonary bypass (CPB).

european journal of cardio-thoracic surgery

Activation of the receptor activator of the nuclear factor- B ligand pathway during coronary bypass surgery: comparison between on- and off-pump coronary artery bypass surgery procedures