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Left atrium (LA) and ventricle (LV) share the mitral annular plane so that the motion and deformation of both chambers are coupled. Purpose To investigate the interdependence between LA and LV strain curves using strain-strain loops. Methods We included 101 patients with a wide range of pathology and selected for having sufficient image quality for both LA and LV analysis. Patients with a mobile interatrial septum and more than mild valvular regurgitation were excluded. LA and LV strains were assessed using speckle tracking in 4 and 2 chambers apical views, using the same cardiac cycle and R-R gating. Strain-strain-loops were reconstructed using LV strain data on the x-axis and corresponding, synchronized LA strain data on the y-axis (Fig .A). Linear regressions were calculated for the entire strain-strain-loop as well as for the three phases of the cardiac cycle (systole, early and late diastole) seperately. LA and LV volumes were also measured on the same images and their ratio was calculated and correlated with the slope of the regression line of the strain-strain loop (Fig. B). Results Our study population comprised normal volunteers (27), amyloidosis (8), hypertrophic cardiomyopathy (6), ischemic disease (19), non-ischemic cardiomyopathy (22), aortic stenosis (13) atrial fibrillation (6). On average, LA and LV strain curves correlated with an R2= 0.92 ± 0.04 for the entire loop, R2= 0.97 ±0.01 in systole, R2= 0.98 ± 0.02 in early diastole and R2= 0.97 ±0.03 late diastole. Further, in the individual patients, the ratio of LV/LA volumes correlated with the LA/LV strain ratio with a slope of ∼1.0 (R2 = 0.8). Conclusions LA and LV deformation are closely coupled. Strain curves have a similar shape throughout the cardiac cycle leading to a tight correlation of strain values from both chambers. The relation of LA and LV strain is dominated by the two chambers" dimensions. Abstract P1281 Figure.

P1281 Are left atrial and left ventricular strains independent from each other?