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Funding Acknowledgements Stockholms Background In young adults born preterm, particularly those with bronchopulmonary dysplasia (BPD), chronic respiratory dysfunction is seen even later in Life, and may lead to pulmonary hypertension and right ventricular (RV) dysfunction. Little is known on RV function in young adult patients with BPD in comparison to healthy Controls . RV strain imaging based on 2D speckle tracking echocardiography (ECHO) allows analysis of myocardial deformation and may improve the assessment of RV function. Aims The purpose of this study was to evaluate RV function using conventional ECHO parameters and 2D-strain in young adults born preterm and with and without BPD, and in healthy controls. Methods 43 patients born preterm (21 with BPD and 22 without BPD) and 20 healthy age-matched Controls with mean age 23 +/- 1.7 y. RV size and function were assessed using conventional parameters (RV diameters, fractional area change (FAC%), tricuspid annular plane systolic excursion (TAPSE), peak systolic velocity of tricuspid annulus (PSV), RV myocardial performance index (MPI)) and 2D-strain of the RV free-wall and Total (free-wall and septum). Results No significant differences were found between the groups in the RV size, RV 2D-strain free-wall or Total, TAPSE or FAC%. Only RV MPI differed significantly between groups, however all values were within normal range (Table 1). There were significant correlations between RV 2D-strain and TAPSE, PSV and RV MPI and, but no correlation between RV 2-D strain and FAC%. RV free-wall strain was higher than RV total strain in all Groups. Conclusion RV function in young patients born preterm, with BPD did not differ significantly from the controls and the subjects born preterm with normal lung function. 2D-strain for RV evaluation was within normal range, suggesting that cardiac complications are rare in young BPD patients. RV MPI combining systolic and diastolic function variables may be a more sensitive measure to distinguish between BPD patients and other groups. Variables Controls mean (SD) without BPD mean (SD) with BPD mean (SD) p = value FAC, % 44 (4.4) 46 (5.6) 48 (5.7) 0.1 TAPSE, mm 23 (3.5) 24 (3.8) 25 (4.2) 0.25 RV MPI 0.2 (0.06) 0.3 (0.09) 0.4 (0.1) &amp;lt;0.05 RV strain Total. % -22 (2.5) -22 (3.3) -22 (2.5) 0.8 RV strain free wall, % -29 (5.6) -27 (4.3) -28 (4.7) 0.57 PSV, cm/s 15 (2.3) 14 (2.0) 15 (2.2) 0.26 Differences in right ventricular (RV) function between the study groups, (BPD – bronchopulmonary dysplasia).

european heart journal. cardiovascular imaging

P740 Right ventricular function evaluated by conventional echocardiography and strain imaging: study in young adults born preterm with and without lung disease