English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Funding Acknowledgements Type of funding sources: None. Background  Ankylosing spondylitis (AS) and psoriatic arthritis (PsA) are chronic multisystem inflammatory disorders that present with articular and extra-articular features. Cardiac dysfunction and pulmonary disease are well-known and commonly reported extra-articular manifestations of AS and PsA.  The inflammatory process can induce respiratory complications, including chest wall restriction, significantly impacting patients" cardiorespiratory status. We aimed to assess pulmonary circulation and right ventricle behaviour during exercise in patients with AS and PsA and to detect the possible effect of chest wall restriction on right heart function. Methods  A total of 45 spondylarthritis patients were enrolled in the study (age 51.5 ± 12.3 years, 82.2% men): 27 of them were diagnosed with AS (20 of them had ankylosis at the time of the study), while 18 had PsA (2 of them in ankylosis). According to a standardized protocol, all subjects underwent resting and exercise stress echocardiography on a semi-recumbent cycle ergometer with an incremental workload up to the maximal tolerated workload. Basic echocardiographic measurements were taken, focusing on the right and left ventricular functions and the systolic pulmonary artery pressure (PASP) at rest, at 50 watts workload, and maximal exercise. During the examination, non-invasive blood pressure measurements, transcutaneous capillary oxygen saturation and continuous ECG recording were performed.  Results PASP did not differ between the AS and PsA patients at rest (15.6 ± 6.7 mmHg vs 13.7 ± 8.3 mmHg; p = ns); however, PASP measured at the maximal workload was significantly higher among AS patients  (31.4 ± 15.9mmHg vs 21.6 ± 12.7mmHg; p &amp;lt; 0.05; Figure 1). PASP did not correlate with the age or the time that passed since the diagnosis. Parameters describing the left and right ventricular systolic and diastolic function did not differ significantly between AS and PsA patients at rest and peak stress. Comparing the LV diastolic parameters of ankylosing patients with non-ankylosing patients irrespective of the underlying disease showed significantly different values in peak E/e"ratio (8.9 ± 3 vs 7.4 ± 1.6; p &amp;lt; 0,05; Figure 2). Conclusion  Exercise stress echocardiography is a promising diagnostic modality in autoimmune diseases. In AS patients, the chest wall restriction may results in elevation of PASP during the exercise. The noninvasive indice of left ventricular filling pressure increases significantly in patients with ankylosis in both groups, explaining the effect of the rigid chest wall on the left ventricular filling. Abstract Figure.  Abstract Figure.

Assessment of pulmonary circulation unit during exercise in patients with ankylosing spondilitis and sporiatic arthritis