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Funding Acknowledgements Type of funding sources: None. Purpose To compare the T2 effects of three T1 mapping sequences of the myocardium at 3T and 1.5T.  Materials and Methods We measured native T1 values by three T1 mapping sequences (FFM, MPI and LONG) and T2 values of 630 consecutive subjects (patients and healthy volunteers) in a mid-ventricular short axis slice by regions of interest (ROIs) placed conservatively within the septal myocardium. Correlations between myocardial T1 and T2 values were analyzed. Results Native T1 values differed significantly depending on the sequence, with MPI providing consistently higher mean values than FFM and LONG, LONG providing higher mean values than FFM (all p &amp;lt; 0.001). T1 by FFM, MPI and LONG in the total population, disease group, non-ischaemic cardiomyopathy group were all weakly related to T2 at 3T. The correlation coefficient of MPI were the highest in the total population and disease group, but there is no significant difference in correlation coefficients (all p &amp;gt; 0.05). Similarly, T1 by FFM, LONG in the total population, disease group, NICM group were all weakly-moderately related to T2 at 1.5T. In the control group, only T1 by MPI was moderately and positively related to T2(r = 0.469, p = 0.037). In the ischaemic cardiomyopathy group, only T1 by MPI was weakly and positively related to T2 (r = 0.334, p = 0.011). In the stress condition, T1 by FFM and MPI was weakly and positively related to T2 (r = 0.280,0.210, p = 0.001,0.012, respectively). Conclusion The T2 effects existed in three T1 mapping sequences of the myocardium in varying degrees, we should consider the potential bias from T2 when analyzing the abnormal T1 values of myocardium. Abstract Figure.

Comparison of the T2 effects of three T1 mapping sequences of the myocardium at 3T and 1.5T