English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

  The inflammatory concept of atherogenesis is the leading one. Its finds development in the endotoxin theory of atherosclerosis, confirmed by numerous experimental studies and a several of clinical observations. But the involvement of lipopolysaccharide (LPS) in atherogenesis in humans has been studied without assessing the morphological changes in the structure of the vascular wall and not included an antibodies response. Existing scales for assessing the risk of developing cardiovascular diseases have a maximum error for patients with an average level risk. We examined 113 patients belonging to one group of cardiovascular risk (&amp;lt;5% on the SCORE scale). We evaluated such indicators, which can be attribution to risk factors and can be application in practice, as the level of LPS in blood plasma, the level of antibodies to the LPS Salmonella minnnesota RE 595 (AB-LPS-1) and LPS Escherichia coli O55 (AB-LPS-2) in serum. A duplex scanning of extracranial brachiocephalic arteries (BCA) and a testing for lipid profile were made. It was revealed that the lipid profile do not allow to evaluate the condition of the BCA wall prior duplex scanning. A significant difference was found in the concentration and frequency of occurrence of LPS and AB-LPS indicators among patients with varying degrees of severity of atherosclerotic lesions of BCA (table). Thus, the inclusion of as risk factors the level of LPS, the concentration of AB-LPS can help in predicting the condition of the carotid arteries wall and, accordingly, in changing the degree of risk in patients at the primary diagnosis level without the participation of high-tech expensive imaging techniques. Simple binary models with high specificity and sensitivity were constructed using cluster analysis to predict the severity of BCA atherosclerosis using concentration of LPS and AB-LPS adapted for practical (figure). Comparison risk factors between groups Parameter Group (by arterial wall state) p-value Intact wall Thickening of TIM ASP Cholesterol, mmol/L 6.43 [6.04; 6.82] 5.81 [4.75; 8.28] 6.63 [5.68; 7.51] 0.2750 LDL, mmol/L 4.43 [4.03; 4.78] 3.64 [3.04; 4.98] 4.74 [3.74; 5.28] 0.0558 HDL, mmol/L 1.09 [0.94; 1.29] 1.21 [1.07; 1.51] 1.13 [0.98; 1.35] 0.3198 Triglycerides, mmol/L 1.72 [1.23; 2.54] 1.21 [0.91; 1.92] 1.48 [0.99; 2.07] 0.2752 Atherogenicity index 4.23 [3.45; 6.32] 3.67 [2.91; 4.48] 4.93 [3.92; 5.68] 0.3532 LPS, EU/ml 0.90 [0.60; 1.52] 0.60 [0.41; 0.98]* 1.20 [0.60; 1.8]* 0.0067* AB-LPS-1, c.o.u.d. 216.0 [132.5; 248.5]* 127.5 [105.75; 221.5] 123.0 [91.00; 187.0]* 0.0444* AB-LPS-2, c.o.u.d. 374.0 [199.0; 481.0] 399.5 [195.75; 451.0] 265.0 [200.0; 399.0] 0.1991 *Result was significant at p&amp;lt;0.05 at post-hoc pairwise comparisons. “Decision tree” for a group of patients Funding Acknowledgement Type of funding source: None

The role of lipopolisaccharide and antibodies to the lipopolysaccharide in the systemic circulation to the cardiovascular risk group determination