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Background Endurance training can be described as long-time activity characterized by high dynamic and low to high power and was proven beneficial in CVD prevention. Nevertheless, studies reported that excessive endurance training can act as double-edged sword inducing the inflammatory response and cell apoptosis. This negative effect can be the reason of exercise duration. Purpose In order to investigate the effect of the training duration we compared and analysed acute vs chronic exercise by using in silico technique and we performed two different bioinformatics analysis: tissue-specific and cardiovascular process specific. Materials Bioinformatics analysis miRNA targets predictions, data filtering and visualization as interaction networks were performed. We used multiMiR 1.4 R package, hemopoiesis, angiogenesis, cardiac muscle functions, muscle hypertrophy process was performed a screening of the GO terms for the presence of the key words using the biomaRt package in R, Gene-gene interaction data were retrieved from String App, Cytoscape. Enrichment analysis of Reactome and KEGG pathways using String App. p&amp;lt;0.05. Results Enrichment analysis of Reactome and Kegg pathways revealed strong regulation of senescence-related pathways, RUNX1 expression and activity, Ca2+ signaling involving AGO genes. For the first time our in silico analysis showed that AGO, HMGA2 genes may be associated with adaptive changes in response to exercise. Importantly, we found, that PI3K/AKT signalling (pathway incusing cell survival, growth, and proliferation) was present only in acute but not in chronic exercise. Conclusions In our analysis long-term training miRNA-gene target interaction was different than the short-term training. As PI3K/AKT signaling was present only in acute exercise, we suggest that not long-term but short-term training can be related with increased cell survival, enhanced cell proliferation, and decreased cell apoptosis. Genes associated cardiac muscle function Funding Acknowledgement Type of funding source: Public grant(s) – National budget only. Main funding source(s): “Preludium” from the National Science Center, Poland

Not chronic exercise but acute exercise is related with increased cell survival, enhanced cell proliferation and decreased cell apoptosis