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Background Inflammatory bowel disease (IBD) is a chronic disease, both influencing patients physical and mental health and thereby interfering with quality of life (QoL). This systematic review aims to assess the effect of psychotherapy on IBD patients’ QoL. Methods A systematic search was conducted on 07 October 2019 using Embase, Medline (Ovid), PubMed, Cochrane, Web of Science, PsycInfo and Google Scholar, to collect all types of clinical trials with psychotherapeutic interventions that measured QoL in IBD patients aged 18 and over. Quality of evidence was assessed using GRADE criteria. Results Out of 2560 articles, 31 studies (32 articles) were included with a total number of 2397 patients. Of the 31 eligible studies, twelve showed a significant positive effect and four had mixed results regarding the impact of psychotherapeutic interventions on QoL. Eight studies were rated as of moderate quality, of which five showed a significant effect. All four studies focussing on patients with active disease showed a positive effect of psychotherapy. No specific preference for a type of psychotherapy, type of disease or psychological condition at baseline was found. No meta-analysis could be performed due to heterogeneity of design, implementation and statistical analyses of the studies. Conclusion Psychotherapeutic interventions can improve QoL in IBD patients, but there is mixed evidence. Patients with active disease seem to profit more from psychotherapy than those in remission. More high quality research is needed to provide tailored psychological therapy to adults with IBD.

P708 The effect of psychotherapy on quality of life in inflammatory bowel disease patients: A systematic literature review