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s of the 13th Congress of ECCO – European Crohn’s and Colitis Organisation S561 exposed to IBD in utero. FC levels also correlated with more proinflammatory bacterial profiles in early life. If confirmed in a larger sample size, these results may suggest evidence of early subclinical inflammation of which duration and consequences need to be further investigated. P876 Prevalence of Clostridium difficile infection among hospitalised inflammatory bowel disease patients in Greece N. Viazis1*, C. Pontas1, E. Belesiotou2, K. Karmiris3, I. Dimas3, M. Fragaki3, G. Paspatis3, M. Banasa4, I. Drygiannakis5, I. Koutroubakis5, S. Maraki6, D. Moschovis7, M. Tzouvala7, F. Kouskoumpekou8, G. Theocharis9, C. Tsolias9, K. Thomopoulos9, G. Apostolopoulos10, V. Stamouli10, E. Zampeli11, G. Axiaris11, S. Michopoulos11, H. Prifti12, G.J. Mantzaris1 1Evangelismos Hospital, Gastroenterology Department, Athens, Greece, 2Evangelismos Hospital, Microbiology Department, Athens, Greece, 3Venizeleio General Hospital, Gastroenterology Department, Heraklion, Greece, 4Venizeleio General Hospital, Microbiology Department, Heraklion, Greece, 5University Hospital Heraklion, Gastroenterology Department, Heraklion, Greece, 6University Hospital Heraklion, Microbiology Department, Heraklion, Greece, 7Nikaia General Hospital, Gastroenterology Department, Athens, Greece, 8Nikaia General Hospital, Microbiology Department, Athens, Greece, 9University Hospital of Patras, Gastroenterology Department, Patras, Greece, 10University Hospital of Patras, Microbiology Department, Patras, Greece, 11Alexandra General Hospital, Gastroenterology Department, Athens, Greece, 12Alexandra General Hospital, Microbiology Department, Athens, Greece Background: Clostridium difficile (C. difficile) is the leading cause of antibiotic-associated colitis and nosocomial diarrhoea. Patients with inflammatory bowel disease (IBD) are at increased risk of developing C. difficile infection (CDI); however, data on the prevalence of CDI in Greece are limited. We sought to determine rates of CDI among hospitalised IBD patients in major tertiary referral hospitals in Greece. Methods: We performed a retrospective analysis of stool culture results from hospitalised patients investigated for diarrhoea that were tested for CDI from January till December 2016. A  rapid immunoenzymatic (EIA) assay (C.diff Quik check, Complete, Techlab, Blacksburg, VA, USA) was used to test for glutamate dehydrogenase (GDH). Toxins A and B were also sought in positive samples, in order to confirm CDI. Finally, CDI prevalence in IBD patients was compared with non-IBD patients. Results: In total 6932 patients were tested for CDI while hospitalised. Among them, 894 patients were found positive for GDH (12.89%), while 339 were also found positive for C. Difficile toxin (4.89%). Therefore, the prevalence of CDI among all hospitalised patients was 1.6/1000 patient-days. Among them, there were 401 IBD patients presenting with diarrhoea and tested for CDI. Sixtytwo patients were found positive for GDH (15.46%), while 30 were also found positive for C.  difficile toxin (7.48%). Therefore, the prevalence of CDI in IBD patients was 2.5/1000 patient-days. The prevalence of CDI among IBD hospitalised patients was significantly higher than non-IBD hospitalised patients (30/401 vs. 309/6531, p = 0.013). Among the 30 IBD patients with CDI, there were 14 men and 16 women, with a mean age of 46 years. Eighteen of them had ulcerative colitis (E1 = 2, E2 = 3, E3 = 13) and 12 Crohn’s disease (A2L1B1 = 3, A2L2B1 = 3, A2L3B1 = 3, A3L1B1 = 2, A3L3B3 = 1). Six of them were receiving biologics, 3 were receiving corticosteroids (one with azathioprine and one with 5-ASA), 9 were on azathioprine monotherapy and 12 on 5-ASA monotherapy. CDI was successfully treated with metronidazole and/or vancomycin in all cases. Conclusions: Data from IBD referral tertiary Greek hospitals show that CDI prevalence is higher in hospitalised IBD patients than those without IBD. CDI is a growing public health issue among hospitalised IBD patients, prompting the need for better preventative measures, as well as for early detection and treatment.