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TOP1288 a novel narrow spectrum kinase inhibitor (NSKI), selectively targets key kinases fundamental to inflammatory cell signalling in innate and adaptive immune responses: p38-alpha MAP kinase, Src family kinases (Src and Lck) and Syk. The present phase 1b study was designed to evaluate TOP1288's safety, tolerability, PK and PD in ulcerative colitis patients

P684 A first clinical trial of a novel narrow spectrum kinase inhibitor TOP1288 in patients with ulcerative colitis