English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background Smoking has been reported to be associated with increased risk of Crohn’s disease (CD) and protect against ulcerative colitis (UC) from the Western population. However, the association are not well studied and there is no report about smoking and disease outcomes in the Asian population. This study is to clarify the influence of smoking in the development and disease outcomes of inflammatory bowel disease (IBD) in Asian population. Methods This case-controlled study was conducted by cross section chart review for smoking status as well as clinical characteristics of IBD patients at the National Taiwan University Hospital (NTUH). Age, sex, co-morbidities (hypertension, diabetes, and hyperlipidemia) matched non-IBD control were identified by using the database from the National Health Interview Survey of Taiwan, with 4 to 1 ratio for IBD patients. Clinical characteristics including disease phenotype, medication usage, times of admissions, times of emergency room (ER) visits, surgery, development of new cancer, survival status, endoscopic severity, laboratory data were retrieved and analyzed. Results A total of 700 IBD patients (UC: 412; CD: 378) diagnosed from January 1963 to 2020 were identified and analyzed for the influence of smoking to outcomes. The median follow-up time of UC and CD was 104 and 85 months, respectively. Among them, 575 patients (UC: 297, CD: 278) with complete information of comorbidities and aged from 12 to 64 years old were enrolled for smocking prevalence analysis. The prevalence of smoking was significantly lower in UC compared to the matched control (20.88% vs 30.39%, p = 0.0003), but there was no difference between CD and the matched control (19.78% vs 22.12%, p = 0.595). UC smokers were associated with less times of admission (1.56 vs. 2.46, p = 0.017), but higher rate of new cancer development (16% vs. 6.67%, p = 0.01), and mortality (16% vs. 4.91%, p = 0.001), when compared to the non-smokers. CD smokers tended to have disease located in terminal ileum (L1) and ileocolon (L3) (p = 0.0067), higher rate of stricturing (B2) and penetrating (B3) disease (p = 0.0328), higher risk of surgery (60.32% vs. 38.27%, p = 0.001) than the non-smokers, but no difference on mortality. Conclusion In Asian IBD population, smoking is a protective factor for UC occurrence and associated with lower hospitalization rate but more cancer and higher mortality. In contrast, smoking has no effect for CD occurrence and mortality but related to more aggressive behavior which resulted in higher surgical rate.

journal of crohn's and colitis

P615 Does smoking really influence the development and the outcomes of Inflammatory Bowel Disease in Asian population? Results from the Taiwanese patients