Open AccessTranscriptional regulation of stress kinase JNK2 in pro-arrhythmic CaMKIIδ expression in the aged atrium
Author(s) -
Xianlong Gao,
Xiaomin Wu,
Jiajie Yan,
Jingqun Zhang,
Weiwei Zhao,
Dominic M. DeMarco,
Yongguo Zhang,
Mamdouh Bakhos,
Gregory A. Mignery,
Jun Sun,
Zhenyu Li,
Michael Fill,
Xun Ai
Publication year - 2018
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvy011
Subject(s) - kinase , atrium (architecture) , microbiology and biotechnology , medicine , endocrinology , biology , atrial fibrillation
c-jun N-terminal kinase (JNK) is a critical stress response kinase that activates in a wide range of physiological and pathological cellular processes. We recently discovered a pivotal role of JNK in the development of atrial arrhythmias in the aged heart, while cardiac CaMKIIδ, another pro-arrhythmic molecule, was also known to enhance atrial arrhythmogenicity. Here, we aimed to reveal a regulatory role of the stress kinase JNK2 isoform on CaMKIIδ expression.
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