Open AccessRegulation of vascular smooth muscle cell calcification by syndecan-4/FGF-2/PKCα signalling and cross-talk with TGFβ
Author(s) -
Samantha Borland,
Thomas Morris,
Shona Borland,
Mark R. Morgan,
Sheila Francis,
Catherine L.R. Merry,
Ann E. Canfield
Publication year - 2017
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvx178
Subject(s) - vascular smooth muscle , fibroblast growth factor , calcification , protein kinase c , microbiology and biotechnology , syndecan 1 , chemistry , signal transduction , fibroblast growth factor 23 , transforming growth factor , medicine , endocrinology , biology , cell , biochemistry , calcium , receptor , smooth muscle , parathyroid hormone
Vascular calcification is a major cause of morbidity and mortality. Fibroblast growth factor-2 (FGF-2) plays an instructive role in osteogenesis and bone development, but its role in vascular calcification was unknown. Therefore, we investigated the involvement of FGF-2 in vascular calcification and determined the mechanism by which it regulates this process.
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