Open AccessDiabetic db/db mice do not develop heart failure upon pressure overload: a longitudinal in vivo PET, MRI, and MRS study on cardiac metabolic, structural, and functional adaptations
Author(s) -
Desiree Abdurrachim,
Miranda Nabben,
Verena Hoerr,
Michael Kuhlmann,
Philipp Bovenkamp,
Jolita Čiapaitė,
Ilvy M. E. Geraets,
Will A. Coumans,
Joost J.F.P. Luiken,
Jan F. C. Glatz,
Michael Schäfers,
Klaas Nicolay,
Cornelius Faber,
Sven Hermann,
Jeanine J. Prompers
Publication year - 2017
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvx100
Subject(s) - medicine , pressure overload , heart failure , endocrinology , diabetic cardiomyopathy , cardiac function curve , diabetes mellitus , glucose uptake , insulin , cardiomyopathy , cardiac hypertrophy
Heart failure is associated with altered myocardial substrate metabolism and impaired cardiac energetics. Comorbidities like diabetes may influence the metabolic adaptations during heart failure development. We quantified to what extent changes in substrate preference, lipid accumulation, and energy status predict the longitudinal development of hypertrophy and failure in the non-diabetic and the diabetic heart.
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