Open AccessAnti-arrhythmic potential of the late sodium current inhibitor GS-458967 in murine Scn5a-1798insD+/− and human SCN5A-1795insD+/− iPSC-derived cardiomyocytes
Author(s) -
Vincent Portero,
Simona Casini,
Maaike Hoekstra,
Arie O. Verkerk,
Isabella Mengarelli,
Luiz Belardinelli,
Sridharan Rajamani,
Arthur A.M. Wilde,
Connie R. Bezzina,
Marieke W. Veldkamp,
Carol Ann Remme
Publication year - 2017
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvx077
Subject(s) - sodium channel , repolarization , electrophysiology , medicine , myocyte , patch clamp , induced pluripotent stem cell , sodium channel blocker , nerve conduction velocity , brugada syndrome , cardiology , endocrinology , chemistry , pharmacology , sodium , biochemistry , organic chemistry , gene , embryonic stem cell
Selective inhibition of cardiac late sodium current (INaL) is an emerging target in the treatment of ventricular arrhythmias. We investigated the electrophysiological effects of GS-458967 (GS967), a potent, selective inhibitor of INaL, in an overlap syndrome model of both gain and loss of sodium channel function, comprising cardiomyocytes derived from both human SCN5A-1795insD+/- induced pluripotent stem cells (hiPSC-CMs) and mice carrying the homologous mutation Scn5a-1798insD+/-.
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