Open AccessPartitioning the heritability of coronary artery disease highlights the importance of immune-mediated processes and epigenetic sites associated with transcriptional activity
Author(s) -
Majid Nikpay,
Alexandre F.R. Stewart,
Ruth McPherson
Publication year - 2017
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvx019
Subject(s) - heritability , biology , genome wide association study , single nucleotide polymorphism , genetics , genetic architecture , epigenetics , missing heritability problem , genetic association , snp , coronary artery disease , genotype , quantitative trait locus , gene , medicine
With the availability of genome-wide genotype data from GWAS studies, it is now possible to compute the genetic relatedness among individuals and estimate its contribution (SNP-based heritability) to phenotypic variance using Mixed-Linear-Models (MLMs). The estimated heritability can be partitioned according to biological features to gain insight into the genetic architecture of a disease. Here, we aimed to examine the genetic structure of coronary artery disease (CAD).
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