Open AccessThe angiotensin II type 2 receptor activates flow-mediated outward remodelling through T cells-dependent interleukin-17 production
Author(s) -
Antoine Caillon,
Céline Grenier,
Linda Grimaud,
Emilie Vessières,
AnneLaure Guihot,
Simon Blanchard,
Eric Lelièvre,
Marie Chabbert,
Etienne Foucher,
Pascale Jeannin,
Céline Beauvillain,
Pierre Abraham,
Laurent Loufrani,
Yves Delneste,
Daniel Henrion
Publication year - 2016
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvw172
Subject(s) - medicine , endocrinology , angiotensin ii , receptor , mesenteric arteries , vascular remodelling in the embryo , chemistry , biology , artery
The angiotensin II type 1 receptor (AT1R) through the activation of immune cells plays a key role in arterial inward remodelling and reduced blood flow in cardiovascular disorders. On the other side, flow (shear stress)-mediated outward remodelling (FMR), involved in collateral arteries growth in ischaemic diseases, allows revascularization. We hypothesized that the type 2 receptor (AT2R), described as opposing the effects of AT1R, could be involved in FMR.
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