Open AccessIs stress response a new link between adipose tissue and atherogenesis? The role of HSPs/HSF1
Author(s) -
Ioannis Akoumianakis,
Charalambos Antoniades
Publication year - 2016
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvw099
Subject(s) - adipose tissue , adipocyte , endocrinology , medicine , lipid metabolism , adipokine , lipid droplet , biology , diabetes mellitus , insulin resistance
The role of lipids in atherogenesis is well established; sub-endothelial deposition of oxidised low density lipoprotein (ox-LDL) initiates atherosclerotic plaque formation. Circulating cholesterol is regulated by its dietary intake and endogenous synthesis on one hand, and its elimination from the circulation via LDL-receptors/excretion in the bile on the other hand.2 Various lipid-lowering therapies targeting these regulatory mechanisms are used in patients with dyslipidaemias, significant impacting cardiovascular risk. However, the residual risk after applying existing lipid-lowering strategies highlights the complexity of lipid metabolism and the necessity for broader understanding of the links between lipids and the cardiovascular system
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