Open AccessBMP-7 attenuates left ventricular remodelling under pressure overload and facilitates reverse remodelling and functional recovery
Author(s) -
David Merino,
Ana V. Villar,
Raquel García,
Mónica Tramullas,
Luis RuizGuerrero,
Catalina Ribas,
Sofía Cabezudo,
J. Francisco Nistal,
María A. Hurlé
Publication year - 2016
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvw076
Subject(s) - pressure overload , fibrosis , muscle hypertrophy , ventricular remodeling , vascular remodelling in the embryo , medicine , bone remodeling , cardiology , endocrinology , heart failure , biology , cardiac hypertrophy
TGF-β regulates tissue fibrosis: TGF-β promotes fibrosis, whereas bone morphogenetic protein (BMP)-7 is antifibrotic. To demonstrate that (i) left ventricular (LV) remodelling after pressure overload is associated with disequilibrium in the signalling mediated by these cytokines, and (ii) BMP-7 exerts beneficial effects on LV remodelling and reverse remodelling.
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