Cathepsin A mediates susceptibility to atrial tachyarrhythmia and impairment of atrial emptying function in Zucker diabetic fatty rats | Zendy

Dominik Linz | Zendy; Mathias Hohl | Zendy; Stefan Dhein | Zendy; Sven Ruf | Zendy; JanChristian Reil | Zendy; Mostafa Kabiri | Zendy; Paulus Wohlfart | Zendy; Sander Verheule | Zendy; Michael Böhm | Zendy; Thorsten Sadowski | Zendy; Ulrich Schotten | Zendy

Open Access

Cathepsin A mediates susceptibility to atrial tachyarrhythmia and impairment of atrial emptying function in Zucker diabetic fatty rats

Author(s) -

Dominik Linz,

Mathias Hohl,

Stefan Dhein,

Sven Ruf,

JanChristian Reil,

Mostafa Kabiri,

Paulus Wohlfart,

Sander Verheule,

Michael Böhm,

Thorsten Sadowski,

Ulrich Schotten

Publication year - 2016

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvw071

Subject(s) - medicine , endocrinology , atrial fibrillation , diabetes mellitus , cardiac function curve , fibrosis , cardiology , heart failure

Type 2 diabetes (T2D) is an independent risk factor for atrial fibrillation (AF) and stroke. The serine protease cathepsin A (CatA) is up-regulated in diabetes and plays an important role in the degradation of extracellular peptides. This study sought to delineate the role of CatA for the development of atrial remodelling under diabetic conditions.

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