Open AccessExosomes induce and reverse monocrotaline-induced pulmonary hypertension in mice
Author(s) -
Jason M. Aliotta,
Mandy Pereira,
Sicheng Wen,
Mark S. Dooner,
Michael Del Tatto,
Elaine Papa,
Laura Goldberg,
Grayson L. Baird,
Corey E. Ventetuolo,
Peter J. Quesenberry,
James R. Klinger
Publication year - 2016
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvw054
Subject(s) - pulmonary hypertension , ventricle , microvesicles , mesenchymal stem cell , medicine , microvesicle , exosome , lung , pharmacology , pathology , immunology , endocrinology , chemistry , microrna , biochemistry , gene
Extracellular vesicles (EVs) from mice with monocrotaline (MCT)-induced pulmonary hypertension (PH) induce PH in healthy mice, and the exosomes (EXO) fraction of EVs from mesenchymal stem cells (MSCs) can blunt the development of hypoxic PH. We sought to determine whether the EXO fraction of EVs is responsible for modulating pulmonary vascular responses and whether differences in EXO-miR content explains the differential effects of EXOs from MSCs and mice with MCT-PH.
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