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This editorial refers to ‘Neural crest-derived resident cardiac cells contribute to the restoration of adrenergic function of transplanted heart in rodent’ by Y. Tamura et al. , pp. 350–357. Cardiac transplantation is currently the best therapeutic approach for some end-stage heart failure patients.1 One consequence following cardiac transplantation is cardiac denervation due to the severance of post-ganglionic sympathetic nerve fibres.2 Interestingly, sympathetic reinnervation takes place within a year or more following transplantation.3 This is accompanied by a significant improvement of heart rate and function in response to exercise, as well as improvement of coronary blood flow.3,4 This recovery of adrenergic function in the transplanted heart has been attributed in part to the activation of the intrinsic cardiac adrenergic system, which can stimulate adrenergic function independent of sympathetic innervation.5,6 Identifying the origin and the mechanisms of activation of the intrinsic cardiac adrenergic system could shed light on sympathetic-related events such as ventricular arrhythmias.7In this issue, Tamura et al. 8 aimed to identify …

Adrenergic function restoration in the transplanted heart: a role for neural crest-derived cells