Open AccessKnockout of p21-activated kinase-1 attenuates exercise-induced cardiac remodelling through altered calcineurin signalling
Author(s) -
Robert T. Davis,
Jillian N. Simon,
Megan S. Utter,
Paul T. Mungai,
Manuel Álvarez,
Shamim Chowdhury,
Ahlke Heydemann,
Yunbo Ke,
Beata M. Wolska,
R. John Solaro
Publication year - 2015
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvv234
Subject(s) - phospholamban , calcineurin , medicine , endocrinology , myofilament , contractility , muscle hypertrophy , cardiac function curve , endurance training , kinase , biology , calcium , myocyte , microbiology and biotechnology , heart failure , transplantation
Despite its known cardiovascular benefits, the intracellular signalling mechanisms underlying physiological cardiac growth remain poorly understood. Therefore, the purpose of this study was to investigate a novel role of p21-activated kinase-1 (Pak1) in the regulation of exercise-induced cardiac hypertrophy.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom