Open AccessEndothelial Gαq/11is required for VEGF-induced vascular permeability and angiogenesis
Author(s) -
Kishor K. Sivaraj,
Rui Li,
Julián Albarrán-Juárez,
Shengpeng Wang,
Denise Tischner,
Myriam Grimm,
Jakub M. Swiercz,
Stefan Offermanns,
Nina Wettschureck
Publication year - 2015
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvv216
Subject(s) - angiogenesis , vegf receptors , vascular permeability , vascular endothelial growth factor a , vascular endothelial growth factor , medicine , microbiology and biotechnology , biology
VEGF A (VEGF-A) is a central regulator of pre- and postnatal vascular development. In vitro studies suggested that heterotrimeric G-proteins of the Gq/11 family contribute to VEGF receptor 2 (VEGFR2) signalling, but the mechanism and physiological relevance of this finding is unknown. The aim of this study is to understand the role of endothelial Gαq/11 in VEGF-dependent regulation of vascular permeability and angiogenesis.
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