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VEGF A (VEGF-A) is a central regulator of pre- and postnatal vascular development. In vitro studies suggested that heterotrimeric G-proteins of the Gq/11 family contribute to VEGF receptor 2 (VEGFR2) signalling, but the mechanism and physiological relevance of this finding is unknown. The aim of this study is to understand the role of endothelial Gαq/11 in VEGF-dependent regulation of vascular permeability and angiogenesis.

Endothelial Gαq/11is required for VEGF-induced vascular permeability and angiogenesis

Endothelial Gα_q/11is required for VEGF-induced vascular permeability and angiogenesis