PKCε-CREB-Nrf2 signalling induces HO-1 in the vascular endothelium and enhances resistance to inflammation and apoptosis | Zendy

Hayley Mylroie | Zendy; Odile Dumont | Zendy; Andrea S. Bauer | Zendy; Clare Thornton | Zendy; John B. G. Mackey | Zendy; Damien Calay | Zendy; Shahir Hamdulay | Zendy; Joan Choo | Zendy; Joseph J. Boyle | Zendy; Allen M. Samarel | Zendy; Anna M. Randi | Zendy; Paul C. Evans | Zendy; Justin C. Mason | Zendy

Open Access

PKCε-CREB-Nrf2 signalling induces HO-1 in the vascular endothelium and enhances resistance to inflammation and apoptosis

Author(s) -

Hayley Mylroie,

Odile Dumont,

Andrea S. Bauer,

Clare Thornton,

John B. G. Mackey,

Damien Calay,

Shahir Hamdulay,

Joan Choo,

Joseph J. Boyle,

Allen M. Samarel,

Anna M. Randi,

Paul C. Evans,

Justin C. Mason

Publication year - 2015

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvv131

Subject(s) - creb , protein kinase c , rottlerin , apoptosis , microbiology and biotechnology , endothelial dysfunction , signal transduction , inflammation , biology , endothelium , endocrinology , medicine , cancer research , chemistry , immunology , transcription factor , biochemistry , gene

Vascular injury leading to endothelial dysfunction is a characteristic feature of chronic renal disease, diabetes mellitus, and systemic inflammatory conditions, and predisposes to apoptosis and atherogenesis. Thus, endothelial dysfunction represents a potential therapeutic target for atherosclerosis prevention. The observation that activity of either protein kinase C epsilon (PKCε) or haem oxygenase-1 (HO-1) enhances endothelial cell (EC) resistance to inflammation and apoptosis led us to test the hypothesis that HO-1 is a downstream target of PKCε.

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