Open AccessLoss of Krox20 results in aortic valve regurgitation and impaired transcriptional activation of fibrillar collagen genes
Author(s) -
Gaëlle Odelin,
Emilie Faure,
Frank Kober,
Corinne Maurel-Zaffran,
Alexis Théron,
Fanny Coulpier,
Benjamin Guillet,
Monique Bernard,
Jean-François Aviérinos,
Patrick Charnay,
Piotr Topilko,
Stéphane Zaffran
Publication year - 2014
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvu233
Subject(s) - extracellular matrix , aortic valve , regurgitation (circulation) , microbiology and biotechnology , cardiac valve , matrix (chemical analysis) , function (biology) , biology , chemistry , cardiology , medicine , chromatography
Heart valve maturation is achieved by the organization of extracellular matrix (ECM) and the distribution of valvular interstitial cells. However, the factors that regulate matrix components required for valvular structure and function are unknown. Based on the discovery of its specific expression in cardiac valves, we aimed to uncover the role of Krox20 (Egr-2) during valve development and disease.
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