Open AccessHistone deacetylase 5 interacts with Krüppel-like factor 2 and inhibits its transcriptional activity in endothelium
Author(s) -
IlSun Kwon,
Weiye Wang,
Suowen Xu,
ZhengGen Jin
Publication year - 2014
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvu183
Subject(s) - krüppel , klf2 , mediator , inflammation , endothelium , histone , microbiology and biotechnology , cancer research , histone deacetylase , endothelial dysfunction , chemistry , transcription factor , medicine , biology , immunology , biochemistry , gene
Vascular endothelial dysfunction and inflammation are hallmarks of atherosclerosis. Krüppel-like factor 2 (KLF2) is a key mediator of anti-inflammatory and anti-atherosclerotic properties of the endothelium. However, little is known of the molecular mechanisms for regulating KLF2 transcriptional activation.
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