Open AccessSCN10A/Nav1.8 modulation of peak and late sodium currents in patients with early onset atrial fibrillation
Author(s) -
Eleonora SavioGalimberti,
Peter Weeke,
Raafia Muhammad,
Marcia Blair,
Sami Ansari,
Laura Short,
Thomas C. Atack,
Kaylen Kor,
Carlos G. Vanoye,
Morten S. Olesen,
LuCamp,
Tao Yang,
Alfred L. George,
Dan M. Roden,
Dawood Darbar
Publication year - 2014
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvu170
Subject(s) - sodium channel , proband , genetics , electrophysiology , minor allele frequency , biology , atrial fibrillation , allele , phenotype , coding region , gene , medicine , allele frequency , mutation , chemistry , sodium , organic chemistry
To test the hypothesis that vulnerability to atrial fibrillation (AF) is associated with rare coding sequence variation in the SCN10A gene, which encodes the voltage-gated sodium channel isoform NaV1.8 found primarily in peripheral nerves and to identify potentially disease-related mechanisms in high-priority rare variants using in-vitro electrophysiology.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom