Open AccessExtracellular vesicles from human cardiac progenitor cells inhibit cardiomyocyte apoptosis and improve cardiac function after myocardial infarction
Author(s) -
Lucio Barile,
Vincenzo Lionetti,
Elisabetta Cervio,
Marco Matteucci,
Mihaela Gherghiceanu,
Laurenţiu M. Popescu,
Tiziano Torre,
Francesco Siclari,
Tiziano Moccetti,
Giuseppe Vassalli
Publication year - 2014
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvu167
Subject(s) - microvesicles , paracrine signalling , microbiology and biotechnology , umbilical vein , exosome , apoptosis , angiogenesis , myocyte , cardiac function curve , secretion , biology , chemistry , cancer research , medicine , microrna , endocrinology , in vitro , heart failure , biochemistry , receptor , gene
Recent evidence suggests that cardiac progenitor cells (CPCs) may improve cardiac function after injury. The underlying mechanisms are indirect, but their mediators remain unidentified. Exosomes and other secreted membrane vesicles, hereafter collectively referred to as extracellular vesicles (EVs), act as paracrine signalling mediators. Here, we report that EVs secreted by human CPCs are crucial cardioprotective agents.
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