Open AccessInsulin resistance aggravates atherosclerosis by reducing vascular smooth muscle cell survival and increasing CX3CL1/CX3CR1 axis
Author(s) -
Sergio MartínezHervás,
Ángela Vinué,
Laura Núñez,
Irene AndrésBlasco,
Laura Piqueras,
José T. Real,
Juan F. Ascaso,
Deborah J. Burks,
MaríaJesús Sanz,
Herminia GonzálezNavarro
Publication year - 2014
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvu115
Subject(s) - insulin resistance , medicine , vascular smooth muscle , type 2 diabetes mellitus , metabolic syndrome , cx3cr1 , type 2 diabetes , vascular disease , cardiology , diabetes mellitus , endocrinology , disease , inflammation , smooth muscle , chemokine , chemokine receptor
Insulin resistance (IR) is a major risk factor for cardiovascular disease and atherosclerosis. Life-threatening acute events are mainly due to rupture of unstable plaques, and the role of vascular smooth muscle cells (VSMCs) in this process in IR, Type 2 diabetes mellitus, and metabolic syndrome (T2DM/MetS) has not been fully addressed. Therefore, the role of VSMC survival in the generation of unstable plaques in T2DM/MetS and the involvement of inflammatory mediators was investigated.
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