Open AccessInhibition of Toll-like receptor 2 reduces cardiac fibrosis by attenuating macrophage-mediated inflammation
Author(s) -
Lei Wang,
Yulin Li,
Congcong Zhang,
Wei Cui,
Wang Xia,
Yong Xia,
Jie Du,
HuiHua Li
Publication year - 2013
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvt258
Subject(s) - tlr2 , inflammation , cardiac fibrosis , fibrosis , angiotensin ii , toll like receptor , innate immune system , chemokine , medicine , receptor , endocrinology , immunology , tlr4
Toll-like receptor 2 (TLR2) is an important player in innate immunity, and recent studies have identified TLR2 as a critical mediator in cardiovascular diseases. Here, we investigated the involvement of TLR2 in angiotensin (Ang) II-induced cardiac fibrosis and the underlying mechanisms.
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